GLP1

A GLP-1 weight loss protocol should be individualized based on the specific medication, medical history, weight-loss goals, and tolerance to side effects. However, a typical evidence-based framework looks like this:

GLP-1 Weight Loss Protocol

Phase 1: Assessment (Week 0)

Baseline Measurements

• Weight

• Waist circumference

• Body fat percentage (if available)

• Blood pressure

• Fasting glucose and HbA1c

• Lipid panel

• Comprehensive metabolic panel

Medical Review

• Current medications

• History of pancreatitis

• Gallbladder disease

• Thyroid cancer history (especially medullary thyroid carcinoma)

• Gastrointestinal disorders

Phase 2: Medication Initiation

Common GLP-1 medications include:

• Semaglutide

• Tirzepatide

• Liraglutide

Example Semaglutide Titration

• Weeks 1–4: 0.25 mg weekly

• Weeks 5–8: 0.5 mg weekly

• Weeks 9–12: 1.0 mg weekly

• Continue gradual increases as prescribed

Example Tirzepatide Titration

• Weeks 1–4: 2.5 mg weekly

• Weeks 5–8: 5 mg weekly

• Increase every 4 weeks as tolerated

Phase 3: Nutrition Strategy

Protein Priority

Aim for:

• 0.7–1.0 grams protein per pound of target body weight

Examples:

• Lean meats

• Fish

• Eggs

• Greek yogurt

• Protein shakes

Hydration

• 80–120 oz water daily

• Electrolyte supplementation if needed

Meal Structure

3 meals daily focused on:

1. Protein

2. Vegetables

3. Healthy fats

4. Fiber-rich carbohydrates

Fiber Goal

• 25–35 grams daily

This helps manage:

• Constipation

• Blood sugar control

• Satiety

Phase 4: Exercise

Resistance Training

3–4 sessions weekly

Focus on:

• Squats

• Hinges/deadlifts

• Push exercises

• Pull exercises

• Core work

Cardiovascular Exercise

• 150 minutes weekly minimum

• Walking is highly effective on GLP-1 therapy

Daily goal:

• 8,000–12,000 steps

Phase 5: Side Effect Management

Nausea

• Eat slowly

• Smaller meals

• Avoid high-fat meals

• Stay hydrated

Constipation

• Increase water

• Increase fiber gradually

• Magnesium supplementation if appropriate

Muscle Loss Prevention

• Prioritize protein

• Strength train consistently

• Avoid excessive calorie restriction

Monitoring Schedule

Monthly

• Weight

• Waist circumference

• Side effects review

• Adherence assessment

Every 3–6 Months

• HbA1c

• Lipids

• Comprehensive metabolic panel

Expected Results

Average outcomes vary by medication and adherence:

• Semaglutide: ~10–15% body weight reduction

• Tirzepatide: ~15–25% body weight reduction

• Higher protein intake and resistance training can help preserve lean muscle mass during weight loss.

For a coaching business, I can also help you create a client-facing 12-week GLP-1 Weight Loss Protocol with:

• Weekly coaching modules

• Meal templates

• Protein targets

• Side-effect management guides

• Progress-tracking forms

• Client handouts branded with your business name.